《生命科学》 2010, 22(2): 103-108

蛋白质合成中的核糖核酸蛋白质复合物

马晶晶，王恩多^*

(中国科学院上海生命科学研究院生物化学与细胞生物学研究所，分子生物学国家重点实验室，上海 200031)

摘　要：摘  要：细胞中的RNA和RNA结合蛋白质(RNA-binding proteins， RBPs)相互作用形成核糖核酸蛋白质(ribonucleoprotein， RNP)复合物。RNP复合物分布广泛，功能众多。蛋白质生物合成包括转录及其调控、mRNA加工转运、tRNA传递、翻译及其调控等，是核酸编码的遗传信息流向活性蛋白质的过程。多种RNA分子参与这一过程，有的与对应的RNA结合蛋白质形成RNP复合物。RNP复合物的多样性和重要功能在此得到了最好的体现。该文以其中起核心作用的RNA分子为主线，对蛋白质合成中的RNP复合物进行了综述。
关键词：蛋白质合成；RNA；核糖核酸蛋白质复合物

Ribonucleoprotein (RNP) complex in protein synthesis

MA Jing-jing， WANG En-duo^*

(State Key Laboratory of Molecular Biology， Institute of Biochemistry and Cell Biology， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 200031， China)

Abstract: Abstract: In cells， RNA and the RNA-binding proteins (RBPs) interact with each other to form RNP complexes which are wide-spread and multi-functional. Protein synthesis is a process in which the genetic code is transferred from nuclear acids to active proteins， consist of transcription and its regulation， mRNA processing and transfer， tRNA transfer， and translation and its regulation. Various RNA molecules participate in this process， some of which form the RNP complexes with cognate RNA-binding proteins. The diversity and functional importance are fully demonstrated in the process of protein synthesis. Here， we summarize the RNP complexes in protein synthesis according to the core RNA molecules.
Key words: protein synthesis; RNA; ribonucleoprotein (RNP) complex