《生命科学》 2010, 22(1): 59-63

病毒介导的细胞融合：癌症发生和发展的新视点

高　鹏，郑　杰^*

东南大学基础医学院 病理与病理生理学系，南京 210009

摘　要：摘　要：细胞融合(cell fusion)具有重要的生理意义。然而，病毒介导的非生理性细胞融合可能促进癌症的发生和发展。相对于基因突变等细胞癌变的传统诱因，病毒的这种致癌机制能够更合理地解释我们在癌症中发现的许多现象。病毒介导的细胞融合可能诱导癌症的观点对我们重新认识病毒相关肿瘤发生发展的机制，并依此调整癌症治疗的策略具有重要意义。
关键词：肿瘤病毒；细胞融合；癌症

Cell fusion mediated by viruses: new insights into initiation and progression of cancer

GAO Peng， ZHENG Jie^*

Department of Pathology and Pathophysiology， School of Basic Medical Science， Southeast University， Nanjing 210009， China

Abstract: Abstract: Cell fusion has crucial physiological significance. Cell fusion mediated by tumor viruses， however， may promote the initiation and progression of cancer. Compared to traditional mutagens， the cell fusion caused by tumor viruses can reasonably explain many phenomena found in some virus-associated cancers. The view that cell fusion mediated by tumor viruses may induce cancer has important significance for understanding the mechanism of virus-associated cancers and based on which adjusting therapy tactics of cancer.
Key words: tumor viruses; cell fusion; cancer