造血干细胞研究进展
刘廷析1，2*
（1中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所干细胞生物学重点实验室和发育与疾病实验室，上海 200025；2上海交通大学医学院瑞金医院，上海血液学研究所医学基因组学国家重点实验室，上海 200025）
摘 要：
摘 要：造血干细胞(hematopoietic stem cell， HSC)是成体干细胞研究领域的范式。对造血干细胞自我更新和不对称分裂分子遗传学机制的诠释，将不仅帮助理解成体干细胞“干性”维持的发育遗传学机制，也将对白血病干细胞和其他类型肿瘤干细胞的发育起源及开发针对肿瘤干细胞的靶向治疗模式产生深远的影响。
关键词：造血干细胞；白血病干细胞；自我更新；模式生物
中图分类号：Q813 文献标识码：A
Research progress of hematopoietic stem cells
LIU Ting-xi1，2*
Abstract:
(1 Key Laboratory of Stem Cell Biology and Laboratory of Development and Diseases， Institute of Health Sciences， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine， Shanghai 200025， China; 2 State Key Laboratory for Medical Genomics， Shanghai Institute of Hematology， Ruijin Hospital， Shanghai Jiao Tong University School of Medicine， Shanghai 200025， China)
Abstract: Hematopoietic stem cell (HSC) is a paradigm of adult stem cells. Understanding the genetic basis of self-renewal and asymmetric division intrinsic to the HSC， will not only help to elucidate the developmental mechanism of “stemness” maintenance in various adult stem cells， but also generate far-reaching impacts on our understanding of developmental origin of leukemia stem cell and other cancer stem cell that can ultimately be targeted in the clinical practice.
Key words: hematopoietic stem cells; leukemia stem cell; self-renewal; model organisms
