《生命科学》 2009, 21(4): 584-588

aac(6)-Ib-cr介导的喹喏酮类新耐药机制研究进展

孙　攀1，殷　瑜2，陈代杰3*

1上海师范大学生命与环境科学学院，上海 200234；2上海来益生物药物研究开发中心，上海 201203；3上海医药工业研究院，上海 200040

摘　要：摘　要：AAC(6{$39})-Ib是重要的氨基糖苷乙酰基团转移酶，其变异基因aac(6{$39})-Ib-cr可同时作用于氨基糖苷类和氟喹诺酮类两类结构不同的抗生素，是引起细菌耐药性的一种重要作用机制。该文主要对aac(6{$39})-Ib-cr介导的喹诺酮类新耐药机制相关研究进行综述。
关键词：细菌耐药性；aac(6{$39})-Ib-cr；喹诺酮类；氨基糖苷类

Research on the new resistance mechanism of quinolones mediated by aac(6)-Ib-cr

SUN Pan1， YIN Yu2， CHEN Dai-jie3*

1 Life and Environment Science College， Shanghai Normal University， Shanghai 200234， China; 2 Health Creation Center for Biopharmaceutical R&D， Shanghai 201203， China; 3 Shanghai Institute of Pharmaceutical Industry， Shanghai 200040， China

Abstract: Abstract: AAC(6{$39})- Ib are important aminoglycoside acetyltransferases.The variable gene aac(6{$39})-Ib-cr acts on both quinolones and aminoglycosides， which belong to different classes of antibiotics based on their chemical structures， leading to the bacteria resistance. This paper briefly reviews the new resisitant mechanism of quinolones mediated by aac(6{$39})-Ib-cr.
Key words: bacteria resistance; aac(6{$39})-Ib-cr; quinolones; aminoglycosides