《生命科学》 2009, 21(3): 357-362

细胞重编程与表观遗传学调控

习佳飞，岳　文， 裴雪涛*

(军事医学科学院输血医学研究所干细胞与再生医学研究室， 北京 100850)

摘　要：摘　要：细胞重编程是生命科学研究的热点之一，目前体细胞核移植、细胞融合和特定转录因子诱导等方法都可以实现体外细胞重编程，而在细胞重编程过程中表观遗传学发挥关键的调控作用，因此对重编程过程中表观遗传学调控机制开展深入研究具有重要的意义。本文简要综述细胞重编程的研究现状和表观遗传学调控细胞重编程机制的研究进展，并对小分子化合物和microRNA提高细胞重编程效率的最新进展进行了介绍。
关键词：细胞重编程；表观遗传学；诱导性多能干细胞

Cellular reprogramming and epigenetic gene regulation

XI Jia-fei， YUE Wen， PEI Xue-tao*

(Stem Cell and Regenerative Medicine Lab， Beijing Institution of Transfusion Medicine， Beijing 100850， China)

Abstract: Abstract: Cellular reprogramming is the process of directing mature cells to a primitive state of gene expression. Now three reprogramming strategies have been studied extensively: somatic cell nuclear transfer， cell fusion， and introduction of specific transcriptional factors. Epigenetic modification is central to genome reprogramming in cellular reprogramming， so a greater understanding of epigenetics will continue to be enlightened by advances in cellular reprogramming. Here we review the recent literature on cellular reprogramming and epigenetic gene regulation mechanisms underlying nuclear reprogramming. We also highlight the research progresses on increasing reprogramming efficiency by using small molecular compound and microRNA.
Key words: cellular reprogramming; epigenetics; induced pluripotent stem cells