《生命科学》 2009, 21(3): 394-399

谷氨酰胺合成酶与Wnt信号转导通路

彭春伟，燕　敏*

(上海交通大学医学院附属瑞金医院外科，上海消化外科研究所，上海市胃肠肿瘤诊治重点实验室，上海 200025)

摘　要：摘　要：GS(glutamine synthetase)或GLUL(glutamate-ammonia ligase)，即谷氨酰胺合成酶，为人体内重要的功能酶，催化谷氨酸与氨生成谷氨酰胺。在体内氮的代谢中，尤其在维持氨离子和谷氨酰胺的稳定中发挥着重要的作用。GS表达和活性的异常常会导致人体很多疾病的发生。近年来研究发现GS表达和活性的异常与Wnt信号通路的异常密切相关。
关键词：谷氨酰胺合成酶; Wnt信号通路; 靶基因

Glutamine synthetase and Wnt-signaling

PENG Chun-wei，YAN-min*

(Shanghai Key Laboratory of Diagnosis and Treatment for Gastrointestinal Cancer， Department of Surgery， Shanghai Institute of Digestive Surgery， Ruijin Hospital， Shanghai Jiao Tong University School of Medicine， Shanghai 200025， China)

Abstract: Abstract: GS is also called glutamine synthetase or glutamate-ammonia ligase， which is an important enzyme in human body. It can catalyze glutamine from glutamate and ammonia. Besides， it plays an important role in nitrogen metabolism， particularly in homeostasis of blood levels of ammonium ions and glutamine. The aberrant expression and activity will cause many human diseases. Recent studies show that the abnormality of its expression and activity has a close relationship with the aberrance of Wnt-signaling.
Key words: glutamine synthetase; Wnt-signaling; target gene