《生命科学》 2009, 21(3): 434-437

鱼类Fc受体研究

邵　茜，安利国，杨桂文*

（山东师范大学 生命科学学院 动物抗性重点实验室，济南 250014）

摘　要：摘　要： Fc受体是免疫细胞表面一种重要受体分子，通过与免疫球蛋白Fc段结合触发多种生物学功能，是联系体液免疫和细胞免疫的桥梁。部分硬骨鱼中已经发现了Fc受体，在斑马鱼、斑点叉尾鮰和鲤鱼中都克隆到了Fc受体的g亚基，在鲨鱼和大西洋鲑中证明有能够与免疫球蛋白结合的Fc受体存在，并在斑点叉尾鮰、河豚和虹鳟中存在着类似a亚基的Fc受体。对鱼类Fc受体的发现和研究必将为了解鱼类的免疫机制及免疫进化提供重要的资料。
关键词：Fc受体；鱼类；免疫 

Advances in the Fc receptor of teleosts

SHAO Qian， AN Li-guo，YANG Gui-wen*

(Key Laboratory of Animal Resistance， College of Life Sciences， Shandong Normal University， Jinan 250014， China)

Abstract: Abstract：Fc receptors(FcRs) of immunoglobulins on immune cell play an important role in  immune system by providing a link between antibody-antigen complexes and the effect cell. FcRs supply an essential link between humoral and cellular immunity. FcRs have been cloned in teleost fish， the g subunit of Fc receptor has been cloned from zebrafish， catfish and common carp， while the subunits binding to immunoglobulins have been identified from shark， atlantic salmon， catfish， fugu and rainbow trout. Identification of subunits of the Fc receptors could lead to a farther investigation of the immune mechanism in teleosts and the phylogeny of Fc receptors.
Key words: Fc receptors(FcRs); teleosts; immunity