《生命科学》 2009, 21(3): 377-382

心肌锚定重复序列蛋白CARP的研究进展

马国达1*，肖兴军2

(1黑龙江八一农垦大学生命科学技术学院，大庆163319；2哈尔滨医科大学附属第二医院神经内科，哈尔滨150086)

摘　要：摘　要：CARP是新发现的具有锚定重复序列，并在哺乳类动物中呈心肌特异性表达的蛋白，它在肌肉发育过程中对转录调控、肌纤维组装和拉伸信号传递等方面发挥重要的作用。本文综述了CARP基因与蛋白质结构、CARP的表达模式及其表达调控、参与调节CARP的细胞内信号转导通路、CARP在肌肉发育中的作用，以及MARP家族其他成员。
关键词：心肌锚定重复序列蛋白；表达调控；肌肉发育

Progress in the study on cardiac ankyrin repeat protein

MA Guo-da1*， XIAO Xing-jun2

(1 College of Biological Science & Technology， Heilongjiang August First Land Reclamation University， Daqing 163319， China; 2 Department of Neurology， the Second Affiliated Hospital of Harbin Medical University， Harbin 150086， China)

Abstract: Abstract: A novel ankyrin-repeated protein， CARP， is specifically expressed in cardiac muscle in mammals. It has been proposed that CARP plays a critical role in transcriptional regulation， myofibrillar assembly and stretch sensing during muscle development. This paper reviews the structure of CARP and its functional role during striated muscle development. The signal pathway involved in CARP expression， and the other members of MARP family.
Key words: cardiac ankyrin repeat protein; expression regulation; muscle development