《生命科学》 2009, 21(3): 408-411

基于受体的药物高通量筛选研究进展

冯璐璐，赵霞霞，李发荣*

（陕西师范大学生命科学学院，西安710062）

摘　要：摘　要：受体是药物筛选的重要靶标，基于受体的药物高通量筛选是药物筛选的主要类型之一。本文根据受体作用原理，按照检测对象的不同，从直接与间接检测的角度，将基于受体的药物高通量筛选进行了分类，总结了基于受体的几种不同的药物筛选模型，并简要介绍了高通量筛选技术在中药研究中的应用，对药物筛选的发展进行了展望。
关键词：受体模型；高通量筛选；中药研究

Progress of high-throughput drug screening based on the receptor model

FENG Lu-lu， ZHAO Xia-xia， LI Fa-rong*

(College of Life Sciences， Shaanxi Normal University， Xi{$39}an 710062， China)

Abstract: Abstract: The receptor is attractive as an important target for drug screening. Receptor-based high-throughput screening is one of the main techniques in modern drug discovery. According to the mechanism of drug-receptor interaction and different object of detection， this paper reviews the classification of the high-throughput screening models based on the receptor， simply introduces the application of high-throughput screening technique in traditional Chinese medicine research， and discusses its future development.
Key words: receptor model; high-throughput screening; Chinese medicine research