《生命科学》 2009, 21(2): 286-290

靶向抑制VEGF在肺癌治疗中的应用前景

郭丽杰1，江其生2*

1辽宁医学院，锦州 121000; 2第二炮兵总医院中心实验室，北京 100088

摘　要：摘　要：血管内皮生长因子(vascular endothelial growth factor， VEGF)是介导肿瘤血管生成最重要因子，与肺癌细胞增殖、转移及预后密切相关。靶向沉默VEGF基因及抑制其受体表达在肺癌治疗中具有光明的应用前景。本文就此进行综述。
关键词：血管内皮生长因子；肺癌；靶向治疗

Application prospect of targeting VEGF in lung cancer

GUO Li-jie， JIANG Qi-Sheng*

1 Liaoning Medical University， Jinzhou 121000， China; 2 General Hospital of the Second Artillery， Beijing 100088， China

Abstract: Abstract: Vascular endothelial growth factor (VEGF) is the best characterized mediator of tumor angiogenesis.The expression of VEGF greatly correlats with the proliferation and metastasis of lung cancer. Studies of targeting VEGF or VEGFR have demonstrated increasing promise in the treatment of lung cancer and will be discussed in this review.
Key words: vascular endothelial growth factor (VEGF);  lung cancer; targeting therapy