《生命科学》 2009, 21(2): 259-263

大气可吸入颗粒物造成肺损伤的NF-kB研究进展

彭　辉，周绮云，刘　璇，赵晓红*

北京联合大学应用文理学院，北京 100083

摘　要：摘　要：NF-kB信号通路在大气可吸入颗粒物(PM10)对肺的损伤过程中起到重要的作用，但NF-kB信号通路参与的损伤机理尚不清楚。本文对NF-kB的结构与组成、颗粒物中NF-kB的激活因素、激活过程和抑制剂的相关研究等内容做简要综述。
关键词：大气可吸入颗粒物；NF-kB信号通路；NF-kB通路抑制剂

Progress of study on the NF-kB signaling pathway in the lung injury induced by inhalable particle

PENG Hui， ZHOU Qi-yun， LIU Xuan， ZHAO Xiao-hong*

College of Applied Arts and Sciences， Beijing Union University， Beijing100083， China

Abstract: Abstract: Many epidemiologic studies have shown that the NF-kB signaling pathway plays an important role in the lung injury by induction of inhaled particle matter. However， the exact toxicological damage mechanisms which the NF-kB signaling pathway takes part in are still unresolved. This paper described the progress of study on the NF-kB signaling pathway in the lung injury induced by inhaled particle matter home and abroad. In this article， the component of NF-kB， the activate factor of NF-kB in particle matter， the activation process and the inhibitor were reviewed.
Key words: inhalable particle; NF-kB signaling pathway; NF-kB signaling pathway inhibitor