《生命科学》 2009, 21(1): 76-80

诱导多能干细胞研究进展

李贵妃，任彩萍*，姚开泰

中南大学肿瘤研究所，长沙 410078

摘　要：摘　要：人类诱导多能干细胞(induced pluripotent stem cells，iPS细胞)的建立被公认为目前最重要的科技进展之一。iPS细胞在动物疾病模型上的成功治疗，病患特异性iPS细胞的研究及iPS细胞的定向分化研究将有可能使人们避开治疗性克隆的伦理和技术障碍，给人类疾病的干细胞治疗带来光明的前景。本文从iPS细胞的诱导策略和方法，来源细胞及筛选、重编程机制的研究现状、应用前景以及研究中存在的问题等方面对其作一综述和讨论。
关键词：诱导多能干细胞；胚胎干细胞；重编程

Progresses in research on induced pluripotent stem cells

LI Gui-fei， REN Cai-ping*， YAO Kai-tai

Cancer Research Institute， Central South University， Changsha 410078， China

Abstract: Abstract:  The establishment of iPS cells (induced pluripotent stem cells， iPS cells) is considered as one of the most important progresses in science and technology nowadays. The successful treatment of an animal disease model by iPS cells and the prospect of deriving patient-specific human iPS cells have underscored the potential use of stem cells for treatment of human diseases. This review discusses the advances in strategies and approaches of induction， original cells and screening， mechanisms of reprogramming， application prospect and obstacles of iPS cells.
Key words:  induced pluripotent stem cells; embryonic stem cells; reprogramming