《生命科学》 2025, 37(12): 1697-1706

LncRNA通过Hippo信号通路调控骨代谢

徐少杰¹ , 欧亿林¹ , 翁锡全^2,3,* , 元　宇^2,3,*

¹广州体育学院研究生院，广州 510500 ²广州体育学院运动与健康学院， 广州 510500 ³广州体育学院广东省运动与健康重点实验室，广州 510500

摘　要：

成骨细胞与破骨细胞主导的骨形成与吸收稳态维持骨代谢动态平衡，但衰老、激素变化等因素可打破这一平衡，诱发骨质疏松症等骨代谢疾病。长链非编码RNA (long noncoding RNAs, lncRNA) 和Hippo信号通路均可广泛参与间充质干细胞、成骨细胞等骨组织细胞分化与功能的调节，对骨代谢发挥重要调控作用。同时，lncRNA 也能通过Hippo 信号通路的核心分子、信号交互及代谢重编程等途径调控骨代谢。然而，国内尚缺乏对lncRNA 通过Hippo 信号通路调控骨代谢作用机制的全面总结。鉴于此，本文综合国内外文献，拟从lncRNA 和Hippo 信号通路切入，总结归纳lncRNA 通过Hippo 信号通路调控骨代谢的核心机制，为防治骨代谢疾病提供理论基础。

通讯作者：翁锡全 , Email:wengxq@gzsport.edu.cn 元　宇 , Email:yuanyumail@126.com

LncRNA regulation of bone metabolism via the Hippo signaling pathway

XU Shao-Jie¹ , OU Yi-Lin¹ , WENG Xi-Quan^2,3,* , YUAN Yu^2,3,*

¹School of Graduate, Guangzhou Sport University, Guangzhou 510500, China ²School of Exercise and Health, Guangzhou Sport University, Guangzhou 510500, China ³Guangdong Key Laboratory of Exercise and Health, Guangzhou Sport University, Guangzhou 510500, China

Abstract:

Osteoblasts and osteoclasts orchestrate bone formation and resorption, maintaining skeletal homeostasis. However, factors like aging and hormonal changes can disrupt this balance, leading to osteoporosis. Both lncRNAs and the Hippo signaling pathway are key regulators of osteoblast and mesenchymal stem cell differentiation and function. LncRNAs can modulate bone metabolism via Hippo pathway components, signaling crosstalk, and metabolic reprogramming. However, there is no research in China that comprehensively sums up the mechanisms of lncRNA in regulating bone metabolism through the Hippo signaling pathway. This paper aims to fill this gap by analyzing how lncRNAs regulate bone metabolism through the Hippo pathway, offering insights for managing bone metabolic disorders.

Communication Author：WENG Xi-Quan , Email:wengxq@gzsport.edu.cn YUAN Yu , Email:yuanyumail@126.com