《生命科学》 2025, 37(12): 1678-1687

细胞内体中Rab蛋白对病毒感染的调控作用研究进展

董平安^1,2,3 , 成荣荣^1,2,3 , 李向茸^1,2,* , 冯若飞^1,2,*

¹西北民族大学生物医学研究中心，细胞基质疫苗关键技术与产业化教育部工程研究中心，兰州 730030 ²西北民族大学生 物医学研究中心，生物工程与技术国家民委重点实验室，兰州 730030 ³西北民族大学生命科学与工程学院，兰州 730030

摘　要：

Rab 蛋白是一类具有分子开关功能的GTP 酶。它们作为细胞内体中的关键调控因子，不仅调控细胞内囊泡运输、信号转导、细胞分裂与融合等生理过程，还广泛参与病毒感染进程。本文系统综述了细胞内体中Rab 蛋白的生物学特性及其功能，重点探讨了其在病毒感染中的调控作用，为深入研究病毒与内体的相互作用机制奠定基础，并为相关病毒性疾病的干预和治疗提供参考。

通讯作者：李向茸 , Email:lixiangrong@xbmu.edu.cn 冯若飞 , Email:fengruofei@xbmu.edu.cn

Research advances in the regulatory role of endosomal Rab proteins in viral infection

DONG Ping-An^1,2,3 , CHENG Rong-Rong^1,2,3 , LI Xiang-Rong^1,2,* , FENG Ruo-Fei^1,2,*

¹Engineering Research Center of Key Technology and Industrialization of Cell-based Vaccine, Ministry of Education, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China ²Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China ³School of Life Sciences and Engineering, Northwest Minzu University, Lanzhou 730030, Ch

Abstract:

Rab proteins are a class of GTPases with molecular switch functions. As key regulatory factors in
endosomes, they not only modulate physiological processes such as intracellular vesicular transport, signal transduction, cell division and fusion, but also extensively participate in viral infection processes. This review systematically summarizes the biological characteristics and functions of Rab proteins in endosomes, and focuses on their regulatory roles in viral infection, laying the foundation for in-depth studies on the interaction mechanism between viruses and endosomes, and providing references for the intervention and treatment of related viral diseases.

Communication Author：LI Xiang-Rong , Email:lixiangrong@xbmu.edu.cn FENG Ruo-Fei , Email:fengruofei@xbmu.edu.cn