《生命科学》 2025, 37(11): 1400-1410

人着床后早期胚胎发育：研究进展和伦理关切

艾宗勇^1,2 , 牛宝华^1,2 , 施高慧^1,2 , 胡颖婕^1,2 , 王云笛¹ , 李天晴^1,2,*

¹昆明理工大学灵长类转化医学研究院，省部共建非人灵长类生物医学国家重点实验 室，昆明 650000 ²云南省中科灵长类生物医学重点实验室，昆明 650000

摘　要：

本文综述了人着床后早期胚胎发育的研究意义、进展及伦理关切。人着床后早期胚胎发育涵盖着床、羊膜囊形成、原肠运动、器官发生、胚外中胚层和原始生殖细胞特化等关键事件，但对其发育机制所知甚少。近年来，人胚胎延长培养、胚胎模型制备以及单细胞和空间转录组测序技术取得显著进展，为深入理解人着床后早期胚胎发育提供了重要工具和新视角。然而，人胚胎和胚胎模型研究涉及诸多伦理问题，如“14天限制”的合理性及胚胎模型的道德地位等。本文就此进行讨论，并提出伦理规制建议，以期为该领域的研究提供参考。

通讯作者：李天晴 , Email:litq@lpbr.cn

Early human post-implantation development: research progress and ethical concerns

AI Zong-Yong^1,2 , NIU Bao-Hua^1,2 , SHI Gao-Hui^1,2 , HU Ying-Jie^1,2 , WANG Yun-Di¹ , LI Tian-Qing^1,2,*

¹State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650000, China ²Yunnan Key Laboratory of Primate Biomedical Research, Kunming 650000, China

Abstract:

This review summarizes the significance, progress, and ethical concerns of research on early human post-implantation development. Key events in early post-implantation development include implantation, amnion formation, gastrulation, organogenesis, extraembryonic mesoderm development, and primordial germ cell specification. However, the underlying developmental mechanisms remain poorly understood. Recent advancements in extended culture of human embryo, embryo model development, and single-cell and spatial transcriptomics have provided new insights and tools for understanding early human embryonic development. However, research involving human embryos and embryo models raises significant ethical issues, such as the rationality of the "14-day rule" and the moral status of embryo models. This review discusses these issues and proposes ethical guidelines to regulate research in this field, providing a reference for future studies.

Communication Author：LI Tian-Qing , Email:litq@lpbr.cn