《生命科学》 2025, 37(10): 1270-1278

靶向TNIK在肿瘤治疗中的研究进展

张来顺^1,2 , 许　磊^2,3,* , 李　佳^1,2,3,4,5,*

¹遵义医科大学，遵义 563006 ²中科中山药物创新研究院，中山 528400 ³中国科学院上海药物 研究所，生命过程小分子调控全国重点实验室，上海 201203 ⁴国科大杭州高等研究院， 杭州 310000 ⁵中科环渤海(烟台)药物高等研究院，烟台新药创制山东省实验室，烟台 264117

摘　要：

TNIK 是STE20 激酶家族成员，正日益受到学术界和药物研发领域的广泛关注。TNIK 与多种蛋白相互作用，参与多条癌症相关信号通路，进而影响细胞的增殖、迁移、分化和代谢，其异常表达与多种肿瘤的发生发展密切相关。因此，靶向TNIK 为治疗癌症提供了一种新的策略，截至目前已报道多项靶向TNIK 治疗癌症的研究。本综述主要对TNIK 的生物学信息、在癌症中的作用、相关抑制剂研究进展进行总结，并重点对TNIK 抑制剂的研发方向、应用前景进行了探讨。

通讯作者：许　磊 , Email:0024xl@zidd.ac.cn 李　佳 , Email:jli@simm.ac.cn

Research progress of targeting TNIK in cancer therapy

ZHANG Lai-Shun^1,2 , XU Lei^2,3,* , LI Jia^1,2,3,4,5,*

¹Zunyi Medical University, Zunyi 563006, China ²Zhongshan Institute for Drug Discovery, Zhongshan 528400, China ³State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China ⁴Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310000, China ⁵Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China

Abstract:

TNIK, a member of the STE20 kinase family, is attracting growing interest from both the academic community and the field of drug discovery research. Through multiprotein interactions, TNIK exerts pleiotropic effects on cancer-relevant pathways, driving the rewiring of proliferative, migratory, differentiative, and metabolic programs. Moreover, abnormal TNIK expression is closely associated with the development and progression of various cancers. As a result, targeting TNIK has emerged as a novel strategy for cancer therapy. To date, multiple studies on TNIK-targeted cancer treatments have been published. This review summarizes the biological characteristics of TNIK, its roles in cancer, the progress in TNIK inhibitor research, and explores the development directions and potential applications of TNIK inhibitors.

Communication Author：XU Lei , Email:0024xl@zidd.ac.cn LI Jia , Email:jli@simm.ac.cn