《生命科学》 2025, 37(10): 1263-1269

机械敏感性离子通道Piezo1在呼吸系统中的研究进展

周紫欣¹ , 俞晨杰² , 徐峥嵘² , 钱晓云^1,*

¹江苏大学鼓楼临床医学院耳鼻咽喉头颈外科，镇江 212000 ²南京大学医学院附属鼓楼医院耳鼻咽喉头颈外科，南京 210000

摘　要：

近年来，哺乳动物体内的一类机械敏感性离子通道——Piezo1，因其在体内各个组织脏器中广泛表达受到国内外的广泛关注与研究。特别是在哺乳动物的机械生物学中，它们被认为扮演至关重要的角色。现有研究表明，Piezo1 在呼吸系统中表达丰富。当机体进行气体交换时，Piezo1 能够敏锐地感知空气对呼吸道及肺周围组织的机械压力影响。Piezo1 离子通道通过感知变化的机械牵张力被激活，进一步调控细胞信号转导途径，从而影响呼吸道的生理及病理生理过程。本文旨在综述Piezo1 机械敏感性离子通道在呼吸系统领域的研究进展，期望能为深入理解呼吸系统疾病的发病机制以及探求新的临床治疗方法提供新思路。

通讯作者：钱晓云 , Email:qxy522@163.com

Research progress of the mechanosensitive ion channel Piezo1 in the respiratory system

ZHOU Zi-Xin¹ , YU Chen-Jie² , XU Zheng-Rong² , QIAN Xiao-Yun^1,*

¹Department of Otolaryngology-Head and Neck Surgery, Gulou Clinical Medical College, Jiangsu University, Zhenjiang 212000, China ²Department of Otolaryngology-Head and Neck Surgery, Drum Tower Hospital, Nanjing University School of Medicine, Nanjing 210000, China

Abstract:

In recent years, Piezo1, a class of mechanosensitive ion channels in mammals, has attracted extensive attention and research at home and abroad because of its wide expression in various tissues and organs in vivo. Especially in the mechanobiology of mammals, they are thought to play a crucial role. Existing studies have shown that Piezo1 is abundantly expressed in the respiratory system. When the body is engaged in gas exchange, Piezo1 is able to perceive the mechanical pressure of air on the tissues around the respiratory tract and lungs. By sensing the change of mechanical traction, the Piezo1 ion channel is activated, which further regulates the cell signal transduction pathway, thereby affecting the physiological and pathophysiological processes of the respiratory tract. The purpose of this article is to review the research progress of Piezo1 mechanosensitive ion channels in the field of respiratory system, hoping to provide new ideas for in-depth understanding of the pathogenesis of respiratory diseases and exploring new clinical treatments.

Communication Author：QIAN Xiao-Yun , Email:qxy522@163.com