《生命科学》 2025, 37(10): 1203-1211

水圈微生物组大数据平台：驱动数据密集型研究范式转型的体系化实践

张国庆^1,* , 刘　婉¹ , 吴祉乐¹ , 周成效² , 李　强¹ , 沈东婧² , 赵国屏¹

¹生物医学大数据中心，中国科学院上海营养与健康研究所，上海 200031 ²中国科学院 上海生命科学信息中心，中国科学院上海营养与健康研究所，上海 200031

摘　要：

随着多组学技术的发展和生态系统研究需求的提升，微生物组研究正加速迈向数据密集型范式。水圈微生物组大数据平台作为“水圈微生物驱动地球元素循环的机制”重大研究计划的技术平台，围绕数据标准制定、汇交机制构建、质量控制优化与知识挖掘实践，探索并推动了研究范式的体系化转型。本文系统梳理了平台在数据组织、元数据治理与智能分析等方面的实践路径，分析其在支撑跨生态系统整合分析、提升研究复用性与发现效率中的作用，评估其在支撑范式演进与未来扩展应用中的潜力，并凝练提出“有数据，立标准；易搜索，促共享；可计算，赋能力”的建设目标与“安全管理、信息共享，技术创新、标准增值，尊重产权、高效利用”的服务理念。

通讯作者：张国庆 , Email:

The hydrosphere microbiome big data platform: a systematic framework driving the shift toward data-intensive research paradigms

ZHANG Guo-Qing^1,* , LIU Wan¹ , WU Zhi-Le¹ , ZHOU Cheng-Xiao² , LI Qiang¹ , SHEN Dong-Jing² , ZHAO Guo-Ping¹

¹Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China ²Shanghai Information Center for Life Sciences, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China

Abstract:

With the development of multi-omics technologies and the increasing complexity of ecosystem research, microbiome studies are transitioning toward a data-intensive paradigm. The Aquatic Microbiome Data Platform, developed as part of the Strategic Priority Research Program on Microbial Mediation of Earth’s Elemental Cycles, supports this paradigm shift through systematized approaches to data standardization, submission, quality control, and knowledge discovery. This review outlines the platform’s technical practices in metadata structuring, heterogeneous data governance, and scalable analytics, and also highlights its role in enabling cross-ecosystem synthesis and promoting reusability and discovery efficiency. The platform’s design philosophy is guided by the principles of "Standardization by Data, Discoverability by Search, Capability by Computation" and the service goals of "Secure Management, Open Sharing, Technological Innovation, Standards Enhancement, Respect for Ownership, and Efficient Utilization".

Communication Author：ZHANG Guo-Qing , Email: