《生命科学》 2025, 37(8): 983-991

牛磺酸抗衰老及其生物合成研究进展

谢泳桃^1,2 , 王旭东² , 叶海峰^1,* , 田进忠^1,*

¹华东师范大学生命科学学院，上海 200241 ²浙江工业大学药学院，杭州 310014

摘　要：

牛磺酸是一种由机体产生的多功能调节因子，能够清除自由基、调节营养代谢，发挥神经保护等功能，在延缓衰老和老龄化相关疾病中有显著效果。在哺乳动物中，牛磺酸主要在肝脏中合成，在血浆、胆汁、唾液和肌肉组织中非常丰富，并与机体衰老密切相关。利用合成生物学技术理念构建牛磺酸细胞工厂，有了初步尝试，但在牛磺酸动态响应元件开发、机体牛磺酸含量智能化控制方面仍有待深入研究。本文全面总结了牛磺酸在抗衰老方面的研究进展，并对未来利用合成生物学技术，以益生菌为底盘细胞合成牛磺酸进行了展望，为新型抗衰老技术体系的开发提供了思路和方案。

通讯作者：叶海峰 , Email:hfye@bio.ecnu.edu.cn 田进忠 , Email:jztian@bio.ecnu.edu.cn

Research progress on anti-aging and biosynthesis of taurine

XIE Yong-Tao^1,2 , WANG Xu-Dong² , YE Hai-Feng^1,* , TIAN Jin-Zhong^1,*

¹School of Life Sciences, East China Normal University, Shanghai 200241, China ²College of Pharmacy, Zhejiang University of Technology, Hangzhou 310014, China

Abstract:

Taurine, an endogenously produced pleiotropic factor, exhibits potent antioxidant activity, modulates nutrient metabolism, and confers neuroprotection, demonstrating remarkable efficacy in delaying aging and mitigating age-related pathologies. In mammals, taurine biosynthesis occurs primarily in the liver via a conserved metabolic pathway. This molecule is abundantly present in plasma, bile, saliva, and muscle tissues, and closely relate to aging. Recent advances have enabled preliminary attempts to engineer microbial cell factories for taurine production using synthetic biology strategies. The in-depth research is still needed in the development of taurine dynamic response elements and the intelligent control of taurine levels within the organism. This review comprehensively summarizes the progress of taurine in anti-aging research and proposes a forward-looking perspective: leveraging probiotic chassis cells for de novo taurine synthesis through synthetic biology. These insights may pave the way for novel geroprotective interventions.

Communication Author：YE Hai-Feng , Email:hfye@bio.ecnu.edu.cn TIAN Jin-Zhong , Email:jztian@bio.ecnu.edu.cn