《生命科学》 2025, 37(8): 947-961

溶瘤细菌与溶瘤病毒前沿进展

袁　嘉 , 左　翼 , 侯晓宇 , 赵佳伟 , 刘　涛^* , 王　永^*

北京大学医学部，北京 100191

摘　要：

基于以基因模块化与可编程化为核心的合成生物学理念，研究者通过理性设计开发了多种新型抗肿瘤治疗策略，其中溶瘤细菌与溶瘤病毒疗法展现出巨大潜力。通过嵌入环境感应、药物递送等功能模块，研究者能够实现对溶瘤细菌和溶瘤病毒治疗活性的精准调控，从而提高治疗的安全性和有效性。本文将详细阐述医学合成生物学理念如何指导设计新型溶瘤细菌和溶瘤病毒疗法，并探讨其在临床抗肿瘤治疗中的应用前景。

通讯作者：刘　涛 , Email:taoliupku@pku.edu.cn 王　永 , Email:yong_wang@pku.edu.cn

Recent advances in oncolytic bacteria and oncolytic virus therapies

YUAN Jia , ZUO Yi , HOU Xiao-Yu , ZHAO Jia-Wei , LIU Tao^* , WANG Yong^*

Peking University Health Science Center, Beijing 100191, China

Abstract:

Guided by the synthetic biology centered on genetic modularization and programmability, researchers have rationally developed a variety of innovative anti-tumor therapeutic strategies, among which oncolytic bacteria and oncolytic viruses have shown great potential. By applying functional modules such as environmental sensing and therapeutic payload delivery, researchers can achieve precise control over the therapeutic activities of oncolytic bacteria and viruses, thereby enhancing the safety and efficacy of treatment. This review elaborates on how the principles of medical synthetic biology inform the design of novel oncolytic bacterial and viral therapies and explores their prospects in clinical cancer treatment.

Communication Author：LIU Tao , Email:taoliupku@pku.edu.cn WANG Yong , Email:yong_wang@pku.edu.cn