《生命科学》 2025, 37(3): 329-336

多肽自组装及其作为药物载体的研究进展

陈文静 , 陈号东 , 赵东欣^*

河南工业大学化学化工学院，郑州 450001

摘　要：

多肽分子通过多种作用力的协同作用，能在一定的条件下发生自组装，从而形成有序的稳定的三维结构与形态，并表现出特殊的性能。加之多肽具有良好的生物相容性和设计灵活性，多肽自组装体具有较高的研究与应用价值。本文对多肽的自组装机制、影响多肽自组装的因素( 氨基酸手性与序列、温度、pH、肽浓度、离子强度、超声波及酶刺激) 以及多肽自组装体在药物输运方面的应用进行了简要总结，希望可以为多肽研究工作者提供一些信息支持。

通讯作者：赵东欣 , Email:dxzhao@haut.edu.cn

Progress in self-assembly of peptides and its applications as drug carriers

CHEN Wen-Jing , CHEN Hao-Dong , ZHAO Dong-Xin^*

School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China

Abstract:

Peptide molecules possess the ability to self-assemble under specific conditions, driven by the concerted influence of various intermolecular forces. This process leads to the formation of well-ordered and stable threedimensional architectures and morphologies, which in turn exhibit unique properties. Moreover, peptides are characterized by their excellent biocompatibility and design flexibility, rendering the study of peptide self-assembly both scientifically intriguing and practically significant. This article provides a concise overview of the mechanisms underlying peptide self-assembly, the factors that influence this process (such as amino acid chirality and sequence, temperature, pH, peptide concentration, ion strength, ultrasound, and enzymatic stimuli), and the application of peptide self-assembly in drug delivery, hoping to provide references for researchers engaged in this field.

Communication Author：ZHAO Dong-Xin , Email:dxzhao@haut.edu.cn