《生命科学》 2025, 37(3): 270-277

转录因子Snail介导EMT/EndMT调控器官纤维化疾病的研究进展

熊天赐¹ , 李玉佩² , 曾　明^1,*

¹中南大学湘雅公共卫生学院卫生毒理系，长沙 410013 ²西安交通大学第一附属医院学科建设办公室，西安 710061

摘　要：

器官或组织纤维化是多种疾病终末期的表现形式，其中上皮/ 内皮- 间质转化(EMT/EndMT) 在器官或组织纤维化过程中发挥举足轻重的作用。锌指转录因子Snail 可通过介导多种途径和通路从而将正常的上皮/ 内皮细胞转化为间充质细胞，参与多种器官纤维化的发生和发展。因此，本文将转录因子Snail 介导的EMT/EndMT 过程在各器官纤维化疾病中的相互调控作用进行综述，为进一步阐明器官纤维化疾病的发病机制及开发治疗策略提供重要的理论基础。

通讯作者：曾　明 , Email:zengming@csu.edu.cn

Research progress of Snail-mediated EMT/EndMT in regulating organ fibrotic diseases

XIONG Tian-Ci¹ , LI Yu-Pei² , ZENG Ming^1,*

¹Department of Health Toxicology, Xiangya School of Public Health, Central South University, Changsha 410013, China ²Discipline Construction Office, The First Affiliated Hospital of Xi 'an Jiaotong University, Xi 'an 710061, China

Abstract:

Organ or tissue fibrosis represents the terminal stage of various diseases, in which epithelial-tomesenchymal transition (EMT) and endothelial-to-mesenchymal transition (EndMT) play pivotal roles in the fibrotic process. The zinc finger transcription factor Snail facilitates the transition of normal epithelial or endothelial cells into mesenchymal cells by mediating multiple pathways and signaling cascades, thereby contributing to the initiation and progression of fibrosis in various organs. This review focuses on the regulatory role of Snail-mediated EMT/EndMT in organ fibrosis, aiming to provide an essential theoretical foundation for further understanding the pathogenesis and developing therapeutic strategies for fibrotic diseases.

Communication Author：ZENG Ming , Email:zengming@csu.edu.cn