《生命科学》 2024, 36(8): 1079-1088

斯钙素家族在消化系统恶性肿瘤中的病理意义

陈昱豪¹ , 姚　添² , 高琳娜¹ , 韩竞翔¹ , 高辉阳¹ , 张　鑫¹ , 黄　河^1,2,*

¹山西医科大学第一临床医学院，太原 030001 ²山西医科大学第一医院胃肠外科，太原 030001)

摘　要：

斯钙素家族(stanniocalcins, STCs) 包括斯钙素-1 (STC1) 和斯钙素-2 (STC2)。斯钙素家族成员在抗炎、抗氧化、细胞保护和血管新生等方面发挥了重要作用。在消化系统恶性肿瘤中，STCs 受到多方面的调控，通过多种方式促进肿瘤细胞增殖、侵袭、转移、免疫逃逸和放化疗抵抗，与肿瘤患者的不良预后密切相关。本文就STCs 的生物学功能及其在消化系统恶性肿瘤中的表达和调控机制以及临床重要性进行综述，并探讨其作为生物标志物和治疗靶点的潜力。

通讯作者：黄　河 , Email:hh93003@163.com

Pathological significance of stannocalcins in malignant tumors of digestive system

CHEN Yu-Hao¹ , YAO Tian² , GAO Lin-Na¹ , HAN Jing-Xiang¹ , GAO Hui-Yang¹ , ZHANG Xin¹ , HUANG He^1,2,*

¹The First Clinical College of Shanxi Medical University, Taiyuan 030001, China ²Department of Gastrointestinal Surgery, The First Hospital of Shanxi Medical University, Taiyuan 030001, China

Abstract:

Stanniocalcins (STCs) include stanniocalcin 1 (STC1) and stanniocalcin 2 (STC2). STCs play an important role in anti-inflammation, anti-oxidation, cytoprotection, angiogenesis, etc. In digestive system malignant tumors, STCs promote tumor cell proliferation, invasion, metastasis, immune escape and chemoradiotherapy resistance through a variety of ways, and are closely related to the poor prognosis of patients with tumors. In this review, the physiological functions of STCs and their expression, regulatory mechanisms and clinical importance in digestive system malignancies are summarized. The potential of STCs as biomarkers and therapeutic targets will be explored.

Communication Author：HUANG He , Email:hh93003@163.com