《生命科学》 2024, 36(2): 200-211

琥珀酰化修饰参与癌症的研究进展

陈彩霞¹ , 高　辉² , 苏丽娅^1,*

¹内蒙古医科大学附属医院成果转化科，内蒙古自治区医学细胞生物学重点实验室， 呼和浩特 010050 ²北京大学肿瘤医院内蒙古医院胸外科，呼和浩特 010000

摘　要：

琥珀酰化是一种新型的翻译后修饰(post-translational modifications, PTM)，是在琥珀酰辅酶A 的介导下将一个负电荷四碳琥珀酰基转移到赖氨酸残基伯胺上的过程。近年来研究发现，琥珀酰化参与多种疾病的发生发展，尤其是可通过酶调节或者非酶方式参与癌症的发生发展。本文对相关调控机制( 包括对代谢途径、组蛋白、肿瘤微环境、氧化还原稳态、DNA 损伤及血管生成的调控) 进行综述，从修饰组学角度探讨了癌症的发病机制，以期为推进癌症的预防治疗提供参考。

通讯作者：苏丽娅 , Email:suliya2307@hotmail.com

Research progress on succinylation modification in cancer

CHEN Cai-Xia¹ , GAO Hui² , SU Li-Ya^1,*

¹Key Laboratory of Medical Cell Biology in Inner Mongolia Autonomous Region, Clinical Medical Research Center, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China ²Thoracic Surgery, Inner Mongolia Hospital, Peking University Cancer Hospital, Hohhot 010000, China

Abstract:

Succinylation, a new type of post translational modification (PTM), involves the transfer of a negatively charged tetracarbosuccinyl group to the primary amine of a lysine residue mediated by succinyl CoA. Succinylation is found involved in the occurrence and development of various diseases by enzymic or nonenzymic regulation, especially in cancer. Here we review the relevant regulatory mechanisms on metabolic pathways, histones, tumor microenvironment, redox homeostasis, DNA damage, and angiogenesis, hoping to provide references to investigate the occurrence and development of cancers from the perspective of PTM, and to promote cancer prevention and treatment.

Communication Author：SU Li-Ya , Email:suliya2307@hotmail.com