《生命科学》 2024, 36(2): 168-176

丙泊酚对创伤后应激障碍治疗作用的研究进展

魏子巍¹ , 陈　凯¹ , 张梦煜¹ , 张丹伟² , 赵君瑜¹ , 于新琦¹ , 刘思雨¹ , 王　佳¹ , 张维宁^1,*

¹江苏大学医学院，镇江 212013 ²镇江市精神卫生中心，镇江 212013

摘　要：

丙泊酚作为一种广泛用于临床的短效静脉麻醉药，其复杂的作用机制和多样的效应促使人们不断探索其更广泛的临床用途。丙泊酚通过抑制中枢神经系统产生镇静催眠的作用，其遗忘效应有望改善焦虑状态，逆转快感缺乏，缓解抑郁症状，并在治疗创伤后应激障碍方面发挥作用。本文介绍了丙泊酚的临床应用现状和创伤后应激障碍的发病机制，综述了丙泊酚在创伤后应激障碍中的影响及可能的作用机制，并探讨了丙泊酚作为一种新的治疗手段应用于创伤后应激障碍及其他神经精神疾病的可能性。

通讯作者：张维宁 , Email:wnzhang@ujs.edu.cn

Research progress on the therapeutic effect of propofol on post-traumatic stress disorder

WEI Zi-Wei¹ , CHEN Kai¹ , ZHANG Meng-Yu¹ , ZHANG Dan-Wei² , ZHAO Jun-Yu¹ , YU Xin-Qi¹ , LIU Si-Yu¹ , WANG Jia¹ , ZHANG Wei-Ning^1,*

¹School of Medicine, Jiangsu University, Zhenjiang 212013, China ²Zhenjiang Mental Health Center, Zhenjiang 212013, China

Abstract:

Propofol is a commonly used intravenous anesthetic in clinical settings due to its short-acting nature. Its intricate mechanism of action and diverse effects have prompted extensive exploration of its broader clinical applications. Propofol effectively induces sedation and hypnosis by suppressing the central nervous system. Furthermore, it exhibits amnestic properties that can alleviate anxiety, reverse anhedonia, alleviate depressive symptoms, and potentially treat posttraumatic stress disorder. This study aims to introduce the clinical application of propofol and the potential pathogenesis of posttraumatic stress disorder. The impact of propofol on posttraumatic stress disorder and its plausible underlying mechanism are thoroughly examined. Additionally, the potential utilization of propofol as a novel therapeutic approach in managing posttraumatic stress disorder and other neuropsychiatric conditions is discussed.

Communication Author：ZHANG Wei-Ning , Email:wnzhang@ujs.edu.cn