《生命科学》 2024, 36(1): 48-54

2023年类器官领域发展态势

施慧琳¹ , 朱锋荣¹ , 徐　萍^1,2 , 靳晨琦¹ , 王　玥^1,*

¹中国科学院上海生命科学信息中心，中国科学院上海营养与健康研究所，上海 200031 ²中国科学院大学，北京 100049

摘　要：

    广义的类器官是一类以干细胞衍生类器官、器官芯片以及这些产品的组合等为代表的仿生组织器官的统称。2023 年，类器官技术快速发展，并愈发成熟，对器官结构和功能的模拟水平持续提升，为器官发生、疾病模拟、药物筛选、精准医疗等多个领域的发展提供了更好的研究工具。与此同时，类器官作为移植组织器官的替代，在再生医学中也开始展现出可观的发展前景。本文从科技、产业两方面对类器官2023 年的发展趋势进行了分析，并对该领域的未来发展进行了展望。

通讯作者：王　玥 , Email:wangyue@sinh.ac.cn

The development trends of organoid in 2023

SHI Hui-Lin¹ , ZHU Feng-Rong¹ , XU Ping^1,2 , JIN Chen-Qi¹ , WANG Yue^1,*

¹Shanghai Information Center for Life Sciences, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China ²University of Chinese Academy of Sciences, Beijing 100049, China

Abstract:

    The broad definition of organoids refers to a group of biomimetic tissue organs represented by stem cell derived organoids, organ chips, and combinations of these products. In 2023, organoid technology is rapidly developing and becoming more mature, continuously improving the level of simulation of organ structure and function, which is of great significance to multiple research fields such as organogenesis, disease simulation, drug screening, and precision medicine. At the same time, as a substitute for transplanted tissue organs, organoid has begun to show considerable development prospects in regenerative medicine. This article analyzes the development trends of organoids in 2023 from the perspectives of technology and industry, and looks forward to the future development of this field.

Communication Author：WANG Yue , Email:wangyue@sinh.ac.cn