《生命科学》 2023, 35(4): 538-545

线粒体移植治疗心血管疾病研究进展

黄　涯 , 孙晓垒 , 孙爱军^* , 葛均波

复旦大学附属中山医院心内科，上海市心血管病研究所，上海 200032

摘　要：

心血管疾病的发病率和死亡率逐年升高，且在世界范围内的疾病负担中占据首位。线粒体功能异常可引起细胞到组织的病变，多种心血管疾病被证实与线粒体功能障碍有关。线粒体移植(mitochondria transplantation, MTP) 是一种新兴的治疗手段，用于治疗因线粒体功能障碍引起的组织损伤。经过十多年从基础实验到临床试验的发展，MTP 在心血管疾病中的治疗作用逐渐被证实，并且备受关注。该文就MTP的研究基础及其在心血管疾病中的研究进展进行综述。

通讯作者：孙爱军 , Email:sun.aijun@zs-hospital.sh.cn

Advances in research about mitochondria transplantation therapy for cardiovascular disease

HUANG Ya , SUN Xiao-Lei , SUN Ai-Jun^* , GE Jun-Bo

Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China

Abstract:

The increasing morbidity and mortality of cardiovascular diseases are emerging as the major burden of diseases in the world. Mitochondrial dysfunction induces pathological changes from cell to tissue, which is proved to regulate various cardiovascular diseases. Mitochondria transplantation (MTP) represents a new therapeutic strategy used to treat tissues injury caused by mitochondrial dysfunction. With the development from basic experiments to clinical trials for last decade, MTP has gradually been verified as an efficient therapeutic strategy for cardiovascular diseases, attracting considerable attention. This article reviews the research basis of MTP and its application in cardiovascular diseases.

Communication Author：SUN Ai-Jun , Email:sun.aijun@zs-hospital.sh.cn