《生命科学》 2022, 34(8): 1001-1009

外泌体在胃癌腹膜转移中的研究进展

王启蒙 , 樊小莉 , 郝慧芳^* , 王志钢

College of Life Sciences, Inner Mongolia University, Hohhot 010070, China

摘　要：

胃癌作为高发的恶性肿瘤之一，具有较高致死率，胃癌腹膜转移发生几率较高是导致患者预后不良的主要原因。外泌体是一种细胞膜内吞形成并分泌的纳米级囊泡，所携带的多种大分子物质在被受体细胞摄入后，发挥信号传递，调节生理过程等作用。外泌体在肿瘤发生发展中的作用近年来逐渐成为热点话题。现对外泌体的特点及功能、胃癌腹膜转移的主要分子机制及外泌体在胃癌腹膜转移形成发展过程中发挥的重要作用进行阐述和总结。

通讯作者：郝慧芳 , Email:111981355@imu.edu.cn

Research progress of exosomes in peritoneal metastasis of gastric cancer

WANG Qi-Meng , FAN Xiao-Li , HAO Hui-Fang^* , WANG Zhi-Gang

内蒙古大学生命科学学院，呼和浩特 010000

Abstract:

Gastric cancer is one of the high incidence malignant tumors worldwide, which has a high mortality rate. Gastric cancer has the high probability of peritoneal metastasis, and it is the main reason for the poor prognosis of patients. Exosomes are nano-sized membrane vesicles that are endocytosed and secreted by cell membranes. Through transfer of various bioactive molecules, exosomes can carry a variety of macromolecular substances, which can play an important role on signal transmission and cancer progression. This review outlines the current knowledge and concepts concerning functions of exosomes and the exosomes involvement in gastric cancer pathogenesis. Moreover, it explains the important role of exosomes in the formation and development of peritoneal metastasis of gastric cancer.

Communication Author：HAO Hui-Fang , Email:111981355@imu.edu.cn