《生命科学》 2022, 34(6): 742-748

习得性无助研究范式和神经机制研究进展

尧　丽^* , 李　雪

成都体育学院，成都 610041

摘　要：

习得性无助是指通过学习形成的对现实的无望和无可奈何的状态，个体在可逃避厌恶情境中表现出逃避学习缺陷和情绪低落等。习得性无助研究范式贴切地模拟了人类习得性无助现象，广泛应用于习得性无助现象及抑郁相关机制的研究。以实验动物和人类被试为对象的研究一致表明，习得性无助行为与主动控制、动机相关的前额叶、纹状体等结构以及五羟色胺、多巴胺系统有关，为习得性无助行为的神经环路机制研究及干预与治疗提供了新思路。

通讯作者：尧　丽 , Email:psycho_yl@163.com

Research paradigms and neural mechanisms of learned helplessness

YAO Li^* , LI Xue

Chengdu Sport University, Chengdu 610041, China

Abstract:

Learned helplessness is defined as the learning of independence between responding and outcome, and describes an escape or avoidance deficit in escapable situations following inescapable stress. Paradigms for a learned helplessness are established and widely applied in animals and human to explore the underlying neural mechanisms. Studies in experimental animals and human have consistently showed that active control and motivation-related structures, such as prefrontal cortex and striatum, as well as serotonin and dopamine systems, are involved in learned helplessness. These results may also have substantial implications for further exploring the neural circuit of learned helplessness, and its treatment.

Communication Author：YAO Li , Email:psycho_yl@163.com