《生命科学》 2022, 34(2): 155-161

胃动素调控动物摄食的研究进展

李　娅¹ , 唐　妮¹ , 张　鑫¹ , 周　波² , 李志琼^1,*

¹四川农业大学动物科技学院，成都 611130 ²四川省农业科学院水产研究所，宜宾 644000

摘　要：

胃动素(motilin, Mln) 作为一种促食欲肽，主要由哺乳动物肠道内分泌细胞产生，其广泛分布于中枢神经系统和外周组织。Mln 具有多种生物学功能，如调控摄食、胃肠运动、消化吸收、脂肪细胞增殖分化和脂质储存等。近年来，Mln 调控动物摄食的作用受到学者们的关注，相关研究主要集中于哺乳类和鸟类。该文就Mln 及其受体的发现、结构、组织表达模式和摄食调节作用及机制进行综述，以期为动物摄食调控和生长研究提供参考依据。

通讯作者：李志琼 , Email:lizhiqiong454@163.com

Research progress of motilin in feeding regulation of animals

LI Ya¹ , TANG Ni¹ , ZHANG Xin¹ , ZHOU Bo² , LI Zhi-Qiong^1,*

¹College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China ²Fisheries Research Institute of Sichuan Academy of Agricultural Sciences, Yibin 644000, China

Abstract:

Motilin (Mln), as an orexigenic peptide, is mainly produced by enteroendocrine cells in mammalian and widely distributed in the central nervous system and peripheral tissues. Mln has a variety of biological functions, such as regulation of feeding, gastrointestinal motility, digestion and absorption, adipocyte proliferation and differentiation, and lipid storage. In recent years, the regulation of Mln on animal appetite has attracted the attention. The relevant researches mainly focus on mammals and birds. This article reviews the discovery, structure, tissue distribution of Mln and Mln receptor and the mechanism of Mln in feeding regulation to provide some basis for the regulation of animal feeding and growth.

Communication Author：LI Zhi-Qiong , Email:lizhiqiong454@163.com