《生命科学》 2021, 33(9): 1153-1160

环状RNA翻译在癌症中的研究进展

潘大维¹ , 赵　源² , 梁佳卉¹ , 周　波^2,* , 刘　娇^3,*

¹陆军特色医学中心消化内科，重庆 400042 ²陆军军医大学基础医学院， 重庆 400038 ³北部战区总医院消化内科，沈阳 110016

摘　要：

环状RNA 是一类有着独特环状结构的非编码RNA，它在生物体内有微小RNA 分子海绵、蛋白质脚手架、调控基因转录、调控可变剪接、进入外泌体等多种经典功能机制。虽然环状RNA 被定义成一种非编码RNA，但随着生物信息学和翻译组学的发展与应用，越来越多的研究发现，环状RNA 是能够被翻译的。该文介绍了现在主要的环状RNA 翻译的调控机制，总结了目前研究环状RNA 翻译的常用数据库，汇总了环状RNA 翻译的蛋白质和多肽在癌症中的最新发现，讨论了环状RNA 翻译的应用前景和问题，旨在促进发现更多由环状RNA 编码的与肿瘤相关的蛋白质和多肽。

通讯作者：周　波 , Email:boom000721@163.com 刘　娇 , Email:liujiao861119@hotmail.com

Advances in circular RNAs translation in cancers

PAN Da-Wei¹ , ZHAO Yuan² , LIANG Jia-Hui¹ , ZHOU Bo^2,* , LIU Jiao^3,*

¹Department of Gastroenterology, Army Characteristic Medical Center, Chongqing 400042, China ²School of Basic Medicine, Army Medical University, Chongqing 400038, China ³Department of Gastroenterology, General Hospital of Northern Theater Command, Shenyang 110016, China

Abstract:

Circular RNA is a class of non-coding RNAs with unique circular structure, and it has classic functional mechanisms in organisms such as microRNA molecular sponges, protein scaffolds, regulating transcription, regulating alternative splicing, packaging into exosomes. Although circular RNA is defined as a kind of non-coding RNA, with the development and application of proteomics bioinformatics and translation profiling, a growing number of studies have found that circular RNA can be translated. In this article, we introduce the main regulatory mechanism of circular RNA translation, summarize the commonly used databases for studying circular RNA translation, describe the latest findings of circular RNA translation in cancer, and discuss the application prospect and problems of circular RNA translation, in order to promote the discovery of more tumor-related proteins and peptides encoded by circular RNAs.

Communication Author：ZHOU Bo , Email:boom000721@163.com LIU Jiao , Email:liujiao861119@hotmail.com