《生命科学》 2021, 33(9): 1089-1095

高乌甲素药理活性的研究进展

张　尹a¹ , 高召兵² , 辛晓明b^1,3,* , 郑月明^2,*

¹上海中医药大学，a.研究生院，b.中药学院，上海 201203 ²中国科学院上海药物研究所， 神经精神疾病研究中心，上海 201203 ³上海健康医学院药学院，上海 201318

摘　要：

高乌甲素是从毛茛科植物高乌头中提取的一种二萜类生物碱，是高乌头的主要药理活性成分之一。高乌甲素作为国内首创的非成瘾性药物，具有镇痛活性好、维持时间久、不良反应少的优势，临床上广泛应用于术后痛和癌症痛等轻中度疼痛的治疗。除此以外，高乌甲素的抗心律失常、抗炎、抗肿瘤及抗癫痫等药理活性也有相关研究。该文就高乌甲素药理活性及机制研究的进展予以综述。

通讯作者：辛晓明b , Email:xmxin1687@163.com 郑月明 , Email:zhengyueming@simm.ac.cn

Research progress on the pharmacological activity of lappaconitine

ZHANG Yin¹ , GAO Zhao-Bing² , XIN Xiao-Ming^1,3,* , ZHENG Yue-Ming^2,*

¹a. Graduate School, b. Traditional Chinese Material Medical, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China ²Center for Neurological and Psychiatric and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China ³School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201203, China

Abstract:

Lappaconitine, a diterpenoid alkaloid extracted from the plants of Aonitum sinomontanum Nakai, is one of the main pharmacological active components of aconitum. As a non-addictive drug originated from China, lappaconitine has the advantages of good analgesic activity, long maintenance time and few adverse reactions. It is widely used in clinic for treatment of postoperative pain, cancer pain and other mild to moderate pain conditions. In addition, the anti-arrhythmic, anti-inflammatory, anti-tumor and antiepileptic activities of lappaconitine have been intensively studied. In this review, the research progress on the pharmacological activities of lappaconitine and the related mechanisms are comprehensively summarized.

Communication Author：XIN Xiao-Ming , Email:xmxin1687@163.com ZHENG Yue-Ming , Email:zhengyueming@simm.ac.cn