《生命科学》 2021, 33(6): 736-741

生物钟基因与肾脏功能和疾病

刘程程¹ , 张嘉阳¹ , 杨光锐² , 陈丽红^1,*

¹大连医科大学医学科学研究院，大连 116044 ²大连理工大学生物工程学院，大连 116024

摘　要：

哺乳动物昼夜节律的产生与生物钟基因的周期性表达密切相关。Bmal1、Clock、Per 和Cry 是研究最为广泛的核心生物钟基因。肾脏在维持机体体液平衡和血压稳态方面发挥重要作用，其多数生理功能均呈现出一定的昼夜节律性，如动脉血压的调节、肾血流量的维持、肾小球滤过率的调控，以及水的重吸收和钠的排泄等都会随昼夜变化而产生节律性振荡。研究表明，核心生物钟基因的变异与许多肾脏疾病的发生发展密切相关。因此，深入了解核心生物钟基因在肾脏功能和疾病中的作用对防治肾脏疾病具有重要意义。

通讯作者：陈丽红 , Email:bjclh2000@163.com

Circadian clock gene in kidney function and diseases

LIU Cheng-Cheng¹ , ZHANG Jia-Yang¹ , YANG Guang-Rui² , CHEN Li-Hong^1,*

¹Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China ²School of Bioengineering, Dalian University of Technology, Dalian 116024, China

Abstract:

In mammals, circadian rhythms for nearly all physiological activities and behaviors are closely related to the periodic expression of circadian clock genes. Bmal1, Clock, Per and Cry are the most widely studied core circadian genes. Kidney is essential for maintaining body fluid balance and blood pressure homeostasis. Most of the renal physiological functions exhibit substantial circadian oscillations, such as arterial blood pressure regulation, renal plasma flow maintenance, glomerular filtration rate of control, water reabsorption and sodium excretion. Moreover, growing evidence has shown that deletion or mutation of core clock genes is closely related to the occurrence and development of kidney diseases. Therefore, it is of great significance to deeply understand the role of the circadian clock genes in kidney function and diseases.

Communication Author：CHEN Li-Hong , Email:bjclh2000@163.com