《生命科学》 2021, 33(6): 687-695

高尔基体基质蛋白GM130的生物学功能研究进展

庞潜潜^*

济宁医学院，济宁 272067

摘　要：

GM130 是第一个被报道的能够调控高尔基体结构维持的基质蛋白，其相关生物学功能研究已经积累了大量的成果，证实了GM130 在细胞中涉及多种生物学功能，包括囊泡运输、糖基化修饰、微管发生、有丝分裂、细胞凋亡、自噬、细胞极性和定向迁移以及溶酶体功能维持等等。目前对GM130 的生物学功能的研究多数是在细胞水平进行的，得到验证的生理功能还较少。该文旨在总结以往对GM130 生物学功能的研究，为GM130 功能异常相关的疾病检测和治疗提供理论依据。

通讯作者：庞潜潜 , Email:pangqianqian@mail.jnmc.edu.cn

Research progress on the biological functions of Golgi matrix protein GM130

PANG Qian-Qian^*

Jining Medical University, Jining 272067, China

Abstract:

GM130 is the first reported Golgi matrix protein with the capability of regulation of the structural maintenance of the Golgi apparatus. The researches on the biological functions of GM130 have accumulated a lot of results, confirming that GM130 is involved in a variety of biological functions, such as the vesicular transport, microtubule generation, cell mitosis, cell apoptosis and autophagy, cell polarity and directional migration, and lysosomal function maintenance, etc. At present, most studies of GM130 are carried out at the cellular level, and the evidence of verified physiological functions is limited. This article aims to summarize the previous researches on the biological functions of GM130 and analyze the involvement of GM130 in the life process to provide theoretical basis for the detection and treatment of diseases related to abnormal GM130 functions.

Communication Author：PANG Qian-Qian , Email:pangqianqian@mail.jnmc.edu.cn