《生命科学》 2021, 33(2): 192-198

九次跨膜超家族蛋白(TM9SF)的表达及功能研究进展

刘佩军^1,2 , 丁　露² , 毛　春^1,2 , 沈小芳² , 郭雅碧¹ , 詹　燕¹ , 颜起文¹ , 柳红勤¹ , 雷德宝¹ , 翟宏宇¹ , 范幸怡¹ , 肖　娟^1,2,*

¹湖北文理学院附属医院，襄阳市中心医院，康复医学科，襄阳 441021 ²湖北文理学院医学院分子医学平台，襄阳 441053

摘　要：

九次跨膜超家族蛋白(transmembrane 9 superfamily proteins，TM9SFs，又称Nonaspanins蛋白)由多个成员构成，目前在哺乳动物中有4个成员被发现(TM9SF1~TM9SF4)。TM9SFs结构上均含有一个大的非胞质区和9个跨膜区，在进化过程中高度保守并广谱表达。尽管目前关于该家族蛋白的功能性研究比较有限，但根据目前已知研究成果，其成员与细胞免疫、感染、自噬、肿瘤侵袭和预后等多种生物功能密切相关。该文汇总了TM9SF1~TM9SF4的表达、功能研究和调控作用，以期为科研工作者后续研究提供参考。

通讯作者：肖　娟 , Email:ju_126@126.com

Research progress on the expression and function of TM9SFs

LIU Pei-Jun^1,2 , DING Lu² , MAO Chun^1,2 , SHEN Xiao-Fang² , GUO Ya-Bi¹ , ZHAN Yan¹ , YAN Qi-Wen¹ , LIU Hong-Qin¹ , LEI De-Bao¹ , ZHAI Hong-Yu¹ , FAN Xing-Yi¹ , XIAO Juan^1,2,*

¹Xiangyang Central Hospital, Affiliated Hospital Of Hubei University of Arts and Science, Xiangyang 441021, China ²Department of Molecular Medicine Laboratory, Hubei University of Arts and Science, Xiangyang 441053, China

Abstract:

Transmembrane 9 superfamily proteins (TM9SFs) are mainly composed of four members in mammals called TM9SF1~TM9SF4. TM9SFs have a large non cytoplasmic region and nine transmembrane regions, which are highly conserved during evolution and widely expressed. Researches concerning the function of these superfamily proteins are limited to date, while mounting evidence suggests that the four members are closely related to many biological functions, such as cellular immunity, infection, autophagy, tumor invasion and prognosis. In this paper, we summarized recent studies on the expression, function and regulation of TM9SF1~TM9SF4, in order to provide reference for future study.

Communication Author：XIAO Juan , Email:ju_126@126.com