《生命科学》 2021, 33(1): 131-137

药物递送载体靶向治疗中枢神经系统淋巴瘤的研究进展

夏　天 , 许佩佩 , 欧阳建^*

南京大学医学院附属鼓楼医院，南京 210003

摘　要：

中枢神经系统淋巴瘤(central nervous system lymphoma, CNSL)少见且治疗困难。目前主流方案多为采用大剂量可通过血脑屏障(blood brain barrier, BBB)的化疗药物静脉给药或治疗有效的药物鞘内注射给药治疗，然而效果欠佳。许多外周疗效佳的化疗药物难以跨越BBB，或进入中枢神经系统(CNS)后难以在肿瘤周围靶向聚集。因此，寻找能够高效穿透BBB，同时精确靶向肿瘤的给药途径成为研究热点。该文对近年国内外研究中关于靶向治疗CNSL的各类药物递送载体进行综述，以期为各类药物载体在CNSL中的治疗提供依据。

通讯作者：欧阳建 , Email:ouyangj211@163.com

Research progress of targeted drug-delivery systems for treatment of central nervous system lymphoma

XIA Tian , XU Pei-Pei , OUYANG Jian^*

Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210003, China

Abstract:

Central nervous system lymphoma (CNSL) is rare and difficult to treat. At present, the mainstream treatment of CNSL is high-dose of chemotherapeutic drugs that can pass through the blood-brain barrier (BBB) by intravenous injection or intrathecal injection. However, such treatments show little benefits. Most chemotherapeutic drugs with good peripheral activities have difficulty in crossing the BBB or targeting and gathering around tumors in CNS. Accordingly, it has become a research hotspot to discover a clever drug delivery system which can efficiently penetrate the BBB and accurately target tumors. This article reviewed all kinds of drug delivery systems for targeted therapy of CNSL in recent years in order to offer basis for the application of various drug delivery systems in CNSL.

Communication Author：OUYANG Jian , Email:ouyangj211@163.com