《生命科学》 2020, 32(3): 257-266

生物陶瓷在组织工程中的应用

王晓亚，常　江*

(中国科学院上海硅酸盐研究所，高性能陶瓷和超微结构国家重点实验室，上海 200050)

摘　要：

摘　要：生物陶瓷材料用于修复人体硬组织历史悠久，近年来已从传统的骨填充替代材料发展到骨组织工程材料，并且逐渐从硬组织修复领域扩展到了软组织再生领域。特别是硅酸盐生物陶瓷，作为一种新型陶瓷材料，因其独特的生物学效应越来越受到研究人员的关注。大量研究表明，通过调控生物陶瓷的化学组成和表面宏微观结构不仅可以促进硬组织再生，还可促进多种软组织再生，为进一步有针对性地设计与开发新型组织工程材料提供了新思路。现结合本课题组近十年的研究，重点介绍磷酸钙及硅酸盐生物陶瓷在多种组织修复及再生中的研究进展，并从材料工程和生物学的角度对生物陶瓷的未来研究方向做了展望。

Application of bioceramics in tissue engineering

WANG Xiao-Ya， CHANG Jiang*

(State Key Laboratory of High Performance Ceramics and Superfine Microstructure，
    Shanghai Institute of Ceramics， Chinese Academy of Sciences， Shanghai 200050， China)

Abstract:

Abstract: Bioceramics have been used for the replacement and repair of damaged hard tissue since 18th century. In recent years， the application of bioceramics has been changing from traditional bone filler and replacement materials to bone tissue engineering materials， and has gradually expanded from the field of hard tissue repair to soft tissue regeneration. Especially silicate bioceramics， a new type of ceramic materials， have been attracting more and more attention due to the unique biological activities. Many studies have shown that the chemical composition and surface macroscopic and microscopic structure of bioceramics can not only stimulate the regeneration of hard tissues， but also promote the regeneration of many soft tissues. These findings provide new ideas for further targeted design and development of new tissue engineering materials. In this paper， the research in the past ten years on bioceramic-based materials for tissue engineering， in particular our research findings in calcium phosphate and silicate bioceramics for both hard and soft tissue regeneration are reviewed， and the future research directions of bioceramics are also prospected from the perspective of materials engineering and biological science.