《生命科学》 2020, 32(1): 54-61
摘 要：摘 要：多种免疫细胞( 如单核细胞等) 经低剂量内毒素预处理后可产生对高剂量内毒素的耐受，这种免疫反应称之为内毒素耐受。内毒素耐受是一种由细胞因子信号通路下游负反馈激活的，具有防止炎症持续性伤害的免疫稳态维持机制，主要调控因子包括IL-10 细胞因子信号通路、细胞因子信号通路抑制因子和IL-1 受体相关激酶。另外，在内毒素耐受免疫反应中存在表观遗传修饰的稳定作用。现就内毒素耐受的主要调控机制及维持机制进行阐述。
Abstract: Abstract: Innate immune cells， such as monocytes， will become more tolerable to subsequent endotoxin after prior exposure to minute amounts of the same endotoxin. This is the so-called endotoxin tolerance. Endotoxin tolerance is activated through negative feedback mechanism， and the main regulatory factors are IL-10 signaling pathway， suppressors of cytokine signaling， and IL-1 receptor-associated kinases. Epigenetic modifications are also critical for the maintenance of endotoxin tolerance. Endotoxin tolerance plays critical role in preventing the sustained damage of long-term inflammation， and maintaining the balance of immune system. In this review， we summarize and discuss the regulatory mechanism and the maintaining mechanism of endotoxin tolerance.
