《生命科学》 2020, 32(1): 38-46

放射性心脏损伤相关miRNA和蛋白质的研究进展

杜海洋，刘安文*

(南昌大学第二附属医院肿瘤科，南昌 330006)

摘　要：摘　要：在恶性肿瘤患者胸部放疗后，晚期放射性心脏损伤(radiation-induced heart disease， RIHD) 逐渐成为影响癌症幸存者生存期的重要原因，并愈来愈引起广泛关注与重视。目前RIHD 发病机制尚不完全清楚，心肌肌钙蛋白(cardiac troponin， cTn)、脑利钠肽(brain natriuretic peptide， BNP) 等传统心脏损伤标志物不能准确预测RIHD 的发生及预后，因此，亟需发掘一些用于监测RIHD 的生物标志物。现就RIHD 相关的miRNA 和蛋白质作为生物标志物方面的研究进展作一综述。

Research progress on radiation-induced heart disease related miRNAs and proteins

DU Hai-Yang， LIU An-Wen*

(Department of Oncology， The Second Affiliated Hospital of Nanchang University， Nanchang 330006， China)

Abstract: Abstract: Radiation-induced heart disease (RIHD) in advanced cancer survivors has gradually been the major cause that shortens the lifetime of malignant tumor patients receiving chest radiotherapy， and is increasingly attracting extensive attention of experts. Up to present， as the pathogenesis of RIHD has not been fully understood， conventional biomarkers of heart injury such as cardiac troponin (cTn)， brain natriuretic peptide (BNP) can not predict the occurrence and prognosis of RIHD accurately， therefore， it is urgent to discover some biomarkers for the monitor of RIHD. This review will focus on research progress on RIHD related miRNAs and proteins as biomarkers.