《生命科学》 2020, 32(1): 29-37

MyoD相关非编码RNA调控骨骼肌生长发育的研究进展

吴怡琦1#，晋大鹏2#，秦本源1，李文霞1，张雪莲1，史文倩1，蔡春波1，高鹏飞1，郭晓红1，李步高1，曹果清1*

(1 山西农业大学动物科技学院，太谷 030801；2 中国农业科学院北京畜牧兽医研究所，北京 100193)

摘　要：摘　要：骨骼肌的生长发育是一个受多种功能性因子调控的精密网络过程，其中MyoD是一种骨骼肌特异性转录因子，能够识别并启动骨骼肌特异基因的转录。非编码RNA是一类具有多种生物功能但不能编码蛋白质的RNA。现就目前与MyoD协同作用，共同参与肌细胞增殖、分化、融合等过程的非编码RNA及其作用机制进行综述，以期为阐明与MyoD相关非编码RNA 的作用机制提供理论参考。

Research progress on the effects of MyoD-related non-coding RNAs on muscle growth and development

WU Yi-Qi1#， JIN Da-Peng2#， QIN Ben-Yuan1， LI Wen-Xia1， ZHANG Xue-Lian1， SHI Wen-Qian1， CAI Chun-Bo1， GAO Peng-Fei1， GUO Xiao-Hong1， LI Bu-Gao1， CAO Guo-Qing1*

(1 College of Animal Science and Veterinary Medicine， Shanxi Agricultural University， Taigu 030801， China; 2 Institute of Animal Sciences， Chinese Academy of Agricultural Sciences， Beijing 100193， China)

Abstract: Abstract: The growth and development of skeletal muscle is a precise network process regulated by multiple functional factors. The MyoD is a skeletal muscle-specific transcription factor that recognizes and initiates the transcription of skeletal muscle-specific genes. Non-coding RNA is a type of RNA that has multiple biological functions but cannot encode proteins. In this paper， we summarized the functions and mechanisms of non-coding RNAs involved in the proliferation， differentiation and fusion of myocytes， aiming to provide theoretical references for the mechanisms of MyoD-related non-coding RNAs.