《生命科学》 2019, 31(7): 699-704

微小RNA-7在脑部的表达调控机制和对生理功能的影响

赵娟娟1，2，岳东旭2，3，郭萌萌2，3，陈　静2，3，唐　琳2，3，徐　林1，2，3*

(1 贵州大学医学院，贵阳 550025；2 贵州省基因检测与治疗特色重点实验室，遵义 563000；3 遵义医学院免疫学教研室，遵义 563000)

摘　要：摘　要：微小RNA-7 (microRNA-7， miR-7) 作为微小RNA 家族成员之一，在机体脑部组织中高表达。研究发现，miR-7 与机体脑部组织的发育、功能维持和病理进程密切相关，提示其可能是一个对脑部生理、病理发生过程具有重要作用的新调节分子。该文综述了近年来关于miR-7 在脑部生理发育和功能中的研究进展，以期为阐明以miR-7 为代表的微小RNA 分子在脑部发育和生理功能发展过程中的作用机制，以及为脑部相关临床疾病的诊断、治疗新策略的开发提供帮助。

The expression regulation mechanism of microRNA-7 and its influence on physiological function in the brain

ZHAO Juan-Juan 1，2， YUE Dong-Xu 2，3， GUO Meng-Meng 2，3， CHEN Jing 2，3， TANG Lin 2，3， XU Lin 1，2，3*

(1 School of Medicine， Guizhou University， Guiyang 550025， China; 2 Guizhou Key Laboratory of Gene Detection and Treatment， Zunyi 563000， China; 3 Department of Immunology， Zunyi Medical University， Zunyi 563000， China)

Abstract: Abstract: MicroRNA-7 (miR-7)， one of the members of microRNA (miRNA) family， is highly expressed in the brain tissue. Studies have shown that miR-7 is closely related to the physiological development， functional maintenance and pathological process of brain tissue， which suggesting that miR-7 may be a new regulatory molecule that plays an important role in the physiological and pathological process of brain. In this paper， we summarize the research progress on the role of miR-7 in the physiological function and development of brain in recent years， in order to provide help for the elucidation of mechanism of miR-7， a representative member of miRNAs molecules， in the physiological function and development of brain， as well as the development of relatedbrain diseases with new clinical diagnosis and treatment strategies.