《生命科学》 2019, 31(7): 693-698

肝再生磷酸酶-2的分子结构与功能研究进展

杜新月，吴琛耘，王兆军*

(上海交通大学医学院免疫学与微生物学系，感染免疫实验室，上海 200025)

摘　要：摘　要：肝再生磷酸酶-2(PRL-2) 在机体正常的细胞、组织和器官，以及大部分的肿瘤中普遍高表达，以其致癌原性被广泛认知，但分子机制尚不明确。近几年的研究发现了PRL-2 的新型结合伴侣——细胞周期蛋白M (cyclin-M， CNNM) 家族，进一步解析PRL-2 的生理生物功能提供新的方向。现总结PRL-2分子在实体瘤、血液肿瘤中的作用，探讨其结构与功能的关系，并对PRL-2及其结合伴侣的生理功能进行全面综述。

Research progress in molecular structure and functions of phosphatase of regenerative liver-2

DU Xin-Yue， WU Chen-Yun， WANG Zhao-Jun*

(Laboratory of Infection and Immunology， Department of Immunology and Microbiology， Shanghai Jiao Tong University School of Medicine， Shanghai 200025， China)

Abstract: Abstract: Phosphatase of regenerative liver-2 (PRL-2)， which is well known for its carcinogenicity， is highly expressed in normal cells， tissues and organs， as well as in most tumors， but the molecular mechanism is still unclear. Recent studies have found a new binding partner of PRL-2: cyclin-M (CNNM) family， which provides a new direction for further research about the physiological and biological functions of PRL-2. This review summarizes the current understanding of the role of PRL-2 in solid tumors and hematological tumors， explores the relationship between its structure and function， and comprehensively reviews the physiological functions of PRL-2 and its binding partners.