《生命科学》 2019, 31(7): 678-685

SUMO化修饰与细胞迁移和侵袭

周　盼，陈　幸，曾　辰，周剑峰，王高翔*

(华中科技大学同济医学院附属同济医院血液内科，武汉 430030)

摘　要：摘　要：小泛素样修饰蛋白(small ubiquitin-related modifier， SUMO) 是一种新发现的泛素样分子，通过共价结合的方式，可逆性修饰靶蛋白，参与其翻译后修饰，调节包括靶蛋白稳定性、亚细胞定位及其功能在内的多种生物学行为。近年研究表明，SUMO 化修饰的异常与诸多病理生理过程相关，尤其是肿瘤的发生发展。该文综述了SUMO 化修饰在非肿瘤和肿瘤细胞迁移和侵袭中的影响和作用机制，可能为相关疾病的治疗提供新的思路。

Sumoylation and its role in cell migration and invasion

ZHOU Pan， CHEN Xing， ZENG Chen， ZHOU Jian-Feng， WANG Gao-Xiang*

(Department of Hematology， Tongji Hospital， Tongji Medical College， Huazhong University of Science and Technology， Wuhan 430030， China)

Abstract: Abstract: Small ubiquitin-like modifier (SUMO) is a new kind of posttranslational modifiers that conjugated to the lysine residues of proteins substrates in a reversible covalent manner. It plays a pivotal role in regulation of many biological behaviors of cells， including protein stability， subcellular location and its functions. Many recent researches demonstrate that dysregulation of sumoylation contributes to many pathophysiological processes， especially in the initiation and progression of cancer. In this review， we briefly outline the sumoyaltion system and summarize its role in migration as well as invasion both in tumor and non-tumor cells and provide new direction to treat the related diseases.