《生命科学》 2019, 31(7): 671-677

靶向星形胶质细胞治疗缺血性脑卒中的研究进展

陈华波1，黄艳丽2，翟立红1，沈小芳1，毛　春2，李　通2，肖　娟1*

(1 湖北文理学院分子医学实验室，襄阳 441053；2 湖北文理学院附属襄阳市中心医院，襄阳 441021)

摘　要：摘　要：缺血性脑卒中(ischemic stroke， IS) 发生后，缺血区星形胶质细胞(astrocyte) 活化，这些反应性星形胶质细胞对缺血区神经元发挥有利和有害双重作用。星形胶质细胞与IS 诱导的谷氨酸功能障碍、线粒体功能障碍和胶质瘢痕形成密切相关，并且在IS 后神经元网络重构中发挥重要调节作用。现重点探讨如何利用星形胶质细胞对IS 发挥保护作用的研究进展。

The research on regulating astrocyte protection function after ischemic stroke

CHEN Hua-Bo1， HUANG Yan-Li2， ZHAI Li-Hong1， SHEN Xiao-Fang1， MAO Chun2， LI Tong2， XIAO Juan1*

(1 Department of Molecular Medicine Laboratory， Hubei University of Arts and Science， Xiangyang 441053， China; 2 Xiangyang Central Hospital， Hubei University of Arts and Science， Xiangyang 441021， China)

Abstract: Abstract: Astrocytes are activated after ischemic stroke (IS). The astrocytes play both deleterious and beneficial roles in ischemic area. Astrocytes are involved in extracellular glutamate dysfunction， mitochondrial dysfunction and glial scar formation， and play an important regulatory role in neuronal network remodeling after IS. In this review， we will focus on the recent progresses regarding to the protection function of astrocytes in IS.