《生命科学》 2019, 31(7): 660-664

肌醇1，4，5-三磷酸受体与阿尔茨海默病

王志恒1，李清华1，柯尊记1，2*

(1 桂林医学院广西脑与认知神经科学重点实验室，桂林 541004；2 上海中医药大学生物化学教研室，神经科学研究中心，上海市健康辨识与评估重点实验室，上海 201203)

摘　要：摘　要：细胞内质网上的肌醇1，4，5-三磷酸受体(inositol 1，4，5-trisphosphate receptors， IP3Rs) 是调节Ca2+释放的重要离子通道。Ca2+ 稳态是维持机体细胞生理功能的重要基础，Ca2+信号参与酶激活、囊泡释放和细胞凋亡等多种细胞过程。研究表明，Ca2+信号异常与阿尔茨海默病(Alzheimer’s disease， AD) 密切相关，神经元中钙信号异常可以导致细胞稳态失衡、突触功能丧失，甚至细胞死亡。现对IP3Rs的生物特性及其介导的Ca2+释放在阿尔茨海默病发生发展过程中的作用进行综述。

The inositol 1，4，5-trisphosphate receptors and Alzheimer’s disease

WANG Zhi-Heng1， LI Qing-Hua1， KE Zun-Ji1，2*

(1 Guangxi Key Laboratory for Brain and Cognitive Neurosciences， Guilin Medical University， Guilin 541004， China; 2 Department of Biochemistry， Center for Neurosciences， Shanghai Key Laboratory of Health Identification and Assessment， Shanghai University of Traditional Chinese Medicine， Shanghai 201203， China)

Abstract: Abstract: Inositol 1，4，5-trisphosphate receptors in the endoplasmic reticulum are important ion channels which regulate calcium (Ca2+) release. Calcium homeostasis is an important basis for maintaining the physiological function of cells in organisms. Calcium signal is involved in many cell processes， such as enzyme activation， vesicle release and cellular apoptosis. Studies have shown that aberrant Ca2+ signal is closely related to Alzheimer’s disease. Abnormal Ca2+ signal in neurons can lead to imbalance of cell homeostasis， loss of synaptic function and even cell death. In this review， we discuss the biological characteristic of IP3Rs and its mediated Ca2+ release in the
    occurrence and development of Alzheimer’s disease.