《生命科学》 2019, 31(4): 385-390

基于嗜盐微生物合成生物学的下一代工业生物技术

杜鹤童，赵倚晴，陈金春*，陈国强*

(清华大学生命科学学院，北京 100084)

摘　要：摘　要：工业生物技术旨在利用微生物生化反应进行工业生产，以获得人们需要的各种化合物或燃料等产品。然而，由于现有的工业生物技术需要在生产过程中保持无菌，会消耗大量的能源和淡水资源，大大增加了成本。嗜盐微生物是一类可以在高盐环境下生长的微生物，其生长环境极端，可以有效避免生产过程中受到其他微生物的污染，是降低工业生物技术成本的可行之道。基于本课题组前期大量研究探索，总结了盐单胞菌合成生物学改造的前沿应用，期待对未来生物制造产生积极的影响。

Next generation industrial biotechnology based on synthetic biology of halophiles

DU He-Tong， ZHAO Yi-Qing， CHEN Jin-Chun*， CHEN Guo-Qiang*

(School of Life Sciences， Tsinghua University， Beijing 100084， China)

Abstract: Abstract: Industrial biotechnology aims to use microorganisms to produce chemicals， biofuels and other products that are commonly made by chemical industries. However， because of the heavy consumption on fresh water and energy during the production process， current industrial biotechnology has a very high production cost. Halophilic bacteria are a class of microorganisms growing under high concentration of salt. The high salt environments can avoid contamination by other microorganisms during the production processes， thus reducing the complexity of industrial biotechnology associated with sterilization processes. Applications of synthetic biology of Halomonas are summarized in this article with a hope to promote current industrial biotechnology into the next generation industrial biotechnology.