《生命科学》 2019, 31(2): 172-177

Sirtuins在卵母细胞成熟过程中的作用

刘照俊，刘二珍，孟　孟，沈星辉*，雷　蕾

(哈尔滨医科大学组织学与胚胎学教研室，哈尔滨 150081)

摘　要：摘　要：卵母细胞成熟包括细胞核和细胞质成熟。核成熟主要涉及染色体的分离，细胞质成熟囊括了一系列复杂的过程。Sirtuins 是NAD+ 依赖的组蛋白去乙酰酶家族，其中，SIRT1、SIRT2、SIRT3、SIRT4、SIRT6、SIRT7 均和减数分裂相关。现综述了卵母细胞成熟过程中细胞核成熟和细胞质成熟的变化及sirtuins 在卵母细胞成熟过程中的作用，并总结了sirtuins 与老龄鼠卵母细胞成熟异常的关系。

The roles of sirtuins in oocyte maturation

LIU Zhao-Jun， LIU Er-Zhen， MENG Meng， SHEN Xing-Hui*， LEI Lei

(Department of Histology and Embryology， Harbin Medical University， Harbin150081， China)

Abstract: Abstract: Oocyte maturation includes nuclear maturation and cytoplasmic maturation. Nuclear maturation mainly involves chromosome segregation， and cytoplasmic maturation encompasses a complex set of processes. Sirtuins are NAD+-dependent histone deacetylase families， in which SIRT1， SIRT2， SIRT3， SIRT4， SIRT6 and SIRT7 are all associated with meiosis. This review summarized the changes in nuclear maturation and cytoplasmic maturation during oocyte maturation and the role of sirtuins in oocyte maturation. Finally， the defects of maturation oocytes from aged mice and the possibility of saving these problems through sirtuins were discussed.