《生命科学》 2019, 31(1): 80-86

肠道菌群与益生菌在衰老及其调控中的研究与应用

王　融，邵祎妍，林佳佳，郑柳杰，杨　欣，傅正伟，倪银华*

(浙江工业大学生物工程学院，杭州 310014）

摘　要：摘　要：衰老引起的机体退行性变化往往伴随着多种慢性疾病的发生，而这些疾病中很多与肠道菌群失调有关。肠道菌群通过参与氧化应激、炎性反应、免疫反应、代谢过程、脑- 肠轴调控等多种途径参与了衰老的进程。因此，肠道微生物是影响衰老相关生活质量的重要指标之一。研究发现，补充合适的益生菌可以减轻炎症，维持肠道内微生物平衡，抑制病原菌，提高免疫力，防控疾病，在一定程度上可以延缓机体的衰老，增加个体的寿命。该文重点描述了肠道菌群与益生菌在衰老相关研究中的应用及其潜在调控机制。

The involvement and application of gut microbiota and probiotics in aging

WANG Rong， SHAO Yi-Yan， LIN Jia-Jia， ZHENG Liu-Jie， YANG Xin， FU ZHENG-Wei， NI Yin-Hua*

(College of Biotechnology and Biological Engineering， Zhejiang University of Technology， Hangzhou 310014， China)

Abstract: Abstract: Aging-related degenerative changes are associated with various chronic diseases， many of which are related to the dysbiosis of intestinal microbiota. The intestinal microbiota are involved in the regulation of oxidative stress， inflammation， immune response， metabolic process， gut-brain axis， and thereby participate in the aging process. Therefore， the homeostasis of microbiome is one of the important indexes that affect the quality of life related with aging. Studies have found that proper probiotics supplementation was associated with decrease of inflammation， maintaining balance of gut microbiota， inhibiting pathogens， enhancing immunity and prevention and treatment of diseases， thereby contributing to the postponement of aging process and extension of life span to some extent. In this review， we mainly described the roles and potential mechanisms of gut microbiota and probiotics in aging-related researches.