《生命科学》 2018, 30(11): 1258-1263

亲和素及其类似物在生物医学工程中的应用

廖诗英，蒋春樊，崔婧婷，张　敏*

(湖北文理学院医学院，襄阳 441053)

摘　要：摘　要：基于与生物素高特异性紧密结合的能力，亲和素及其类似物广泛地应用于生物医学工程的多个领域，包括从简单的亲和纯化到复杂的药物定向运输等。研究发现，通过改造亲和素及其类似物与生物素的结合方式，可以改善它们的功能特性，进而开发出纳米适配器和分子水凝胶等系统。现概述亲和素及其类似物与生物素作用的模式，以及目前在亲和纯化、医学信号检测、药物运输、疫苗研制和组织工程等方面的研究与应用，为进一步开发该非共价相互作用提供参考。

Application of avidin and its analogues in biomedical engineering

LIAO Shi-Ying， JIANG Chun-Fan， CUI Jing-Ting， ZHANG Min*

(Medical College， Hubei University of Arts and Science， Xiangyang 441053， China)

Abstract: Abstract: Based on its ability to bind to biotin with the high specificity， avidin and its analogues have been extensively utilized in diverse fields of biomedical engineering， including affinity purification， complicated drug delivery and so on. Several chemically engineered avidin and its analogues have been studied to improve the interactional properties and functional characteristics to develop nanoscale adapters and molecular hydrogel systems. The interacting model between biotin and avidin and its analogues was introduced， and their applications on affinity purification， medical diagnose， drug delivery， vaccine development and tissue engineering were reviewed. These information may provide guides for exploring this non-covalent interaction in biotechnological and biomedical fields.