《生命科学》 2018, 30(9): 1019-1029

CRISPR基因编辑技术发展态势分析

王慧媛1，范月蕾1，褚　鑫2，于建荣1*

(1 中国科学院上海生命科学信息中心，上海 200031；2 中国科学院重大科技任务局，北京 100864)

摘　要：摘　要：近年来，以CRISPR 为代表的基因组编辑技术发展迅速，围绕该技术的一系列基础和应用研究成为全球研究热点。现基于Web of Science 信息检索平台中的SCI-Expanded 来源数据库，结合文献计量、重要进展以及相关的伦理讨论，对CRISPR 为代表的基因组编辑技术发展态势进行分析，为相关研究提供参考。

Trends and development analysis of genome editing technology focusd on CRISPR

WANG Hui-Yuan1， FAN Yue-Lei 1， CHU Xin2， YU Jian-Rong1*

(1 Shanghai Information Center of Life Science， Chinese Academy of Sciences， Shanghai 200031， China; 2 Bureau of Major R&D Programs， Chinese Academy of Sciences， Beijing 100864， China)

Abstract: Abstract: In recent years， new genome editing technologies based on novel and efficient DNA targets have been widely applied in different biological and life science research area， especially the clustered regulatory interspaced short palindromic repeats CRISPR/Cas-based RNA-guided DNA endonucleases (CRISPR/Cas). In this paper， based on SCI-Expanded database in Web of Science，trend and development of genome editing technology research focused on CRISPR are analyzed through bibliometric methods.